lncRNA DLEU2 promotes gastric cancer progression through ETS2 via targeting miR-30a-5p

Abstract Background Gastric cancer (GC) remains an important worldwide. Further understanding of the molecular mechanisms gastric carcinogenesis will enhance diagnosis and treatment GC. Methods The expression DLEU2 ETS2 was analyzed in several GC cell lines using GEPIA online analyze, qRT-PCR immunohistochemistry. biological behavior cells detected by CCK8, clone formation, transwell, wound healing, western blot, flow cytometry assay. More in-depth were studied. Results significantly up-regulated tissues lines. associated with pathological grading TNM stage patients. Furthermore, knockdown inhibited proliferation, migration, invasion AGS MKN-45 cells, while overexpression promoted HGC-27 cells. MiR-30a-5p could directly bind to 3’ UTR region ETS2. Moreover, bound miR-30a-5p through same binding site, which facilitated Knockdown reduced protein level intracellular AKT phosphorylation, induced phosphorylation AKT. highly expressed tissues. age, grading, stage. proliferation migration rescued inhibition down-regulation up-regulation Conclusions is a potential target for treatment.